Friday, January 20, 2017

Tumor Growth and CBD Treatment

A very interesting entry at the .GOV site about the suppression of tumor growth by CBD treatment. While more technical than might be appreciated by the average reader, the statements below (copied from the .gov site) suggest that tumor growth might be stunted by the use of CBD. For additional reading on this topic, please visit the .gov site to view the entire paper using the link at the end of the post.

We evaluated the ability of cannabidiol (CBD) to impair the migration of tumor cells stimulated by conditioned medium. CBD caused concentration-dependent inhibition of the migration of U87 glioma cells, quantified in a Boyden chamber. Since these cells express both cannabinoid CB1 and CB2 receptors in the membrane, we also evaluated their engagement in the antimigratory effect of CBD. The inhibition of cell was not antagonized either by the selective cannabinoid receptor antagonists SR141716 (CB1) and SR144528 (CB2) or by pretreatment with pertussis toxin, indicating no involvement of classical cannabinoid receptors and/or receptors coupled to Gi/o proteins. These results reinforce the evidence of antitumoral properties of CBD, demonstrating its ability to limit tumor invasion, although the mechanism of its pharmacological effects remains to be clarified. 

See more on the .gov site.




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